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Gene : ADAMTS5 Homo sapiens

Name  ? ADAM metallopeptidase with thrombospondin type 1 motif 5 Cytological Location  21q21.3
Brief Description  ADAM metallopeptidase with thrombospondin type 1 motif 5
description  This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016]
  • synonyms:
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2),
  • ADMP-2,
  • HGNC:221,
  • ADAMTS11,
  • ADAMTS-5,
  • ADMP-2,
  • uc002ymg.4,
  • ADAMTS5,
  • AF142099,
  • OTTHUMG00000078686,
  • aggrecanase-2,
  • ADAMTS-11,
  • ADAMTS11,
  • ADAM-TS 5,
  • NM_007038,
  • ADAM-TS5,
  • ADAM-TS 11
  • identifiers:
  • 11096,
  • ENSG00000154736,
  • ADAMTS5

Genome feature

Region: gene ? Length: 49847  
Location: 21:26917912-26967758 reverse strand Cyto location: 21q21.3


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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Proteins

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SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

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Other

243 SN Ps

4 Cross References

15 Data Sets

33 Homologues

0 Located Features

90 Rna Seq Results