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Gene : CAPN10 Homo sapiens

Name  ? calpain 10 Cytological Location  2q37.3
Brief Description  calpain 10
description  Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010]
  • synonyms:
  • HGNC:1477,
  • NM_023083,
  • OTTHUMG00000133358,
  • AF089088,
  • uc002vzk.2,
  • CANP10,
  • NIDDM1,
  • CAPN10
  • identifiers:
  • 11132,
  • ENSG00000142330,
  • CAPN10

Genome feature

Region: gene ? Length: 12394  
Location: 2:240586716-240599109 Cyto location: 2q37.3


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Function

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Gene --> GO terms.

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Proteins

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SNPs

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Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Mouse Gene --> Allele [Phenotype]

Homology

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Expression

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Other

877 SN Ps

5 Cross References

18 Data Sets

22 Homologues

0 Located Features

90 Rna Seq Results