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Gene : LOC111718489 Homo sapiens

Name  ? skeletal muscle cis-regulatory module in APOA4 and APOC3 intergenic region Cytological Location  11q
description  This genomic region, which is located between the apolipoprotein A4 (APOA4) and apolipoprotein C3 (APOC3) genes on chromosome 11, represents a cis-regulatory module (CRM) that functions as an enhancer in skeletal muscle. This element was randomly selected as a conserved intergenic region with a high regulatory potential score. A sub-regoin was shown to drive selective reporter gene expression in differentiated C2C12 myotubes. Another sub-region was validated as a functional enhancer by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in HepG2 liver carcinoma cells (group: HepG2 Activating DNase matched - State 5:Enh, candidate strong enhancer, open chromatin). It also displayed weak activation by Sharpr-MPRA in K562 erythroleukemia cells (group: K562 Activating DNase unmatched - State 8:EnhW, candidate weak enhancer and open chromatin). [provided by RefSeq, Feb 2018]
  • identifiers:
  • 111718489,
  • LOC111718489

Genome feature

Region: gene ?
Location: No location information in HumanMine Cyto location: 11q

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