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Gene : RNF139 Homo sapiens

Name  ? ring finger protein 139 Cytological Location  8q24.13
Brief Description  ring finger protein 139
description  The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]
  • synonyms:
  • translocation in renal carcinoma, chromosome 8,
  • uc003yrc.4,
  • OTTHUMG00000165072,
  • AF064801,
  • NM_007218,
  • HRCA1,
  • TRC8,
  • HGNC:17023,
  • TRC8,
  • RCA1,
  • HRCA1,
  • RCA1,
  • RNF139
  • identifiers:
  • 11236,
  • ENSG00000170881,
  • RNF139

Genome feature

Region: gene ? Length: 13852  
Location: 8:124474767-124488618 Cyto location: 8q24.13


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Function

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Proteins

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SNPs

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Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Homology

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Interactions

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Expression

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Other

8 SN Ps

5 Cross References

17 Data Sets

7 Homologues

0 Located Features

90 Rna Seq Results