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Gene : DUSP12 Homo sapiens

Name  ? dual specificity phosphatase 12 Cytological Location  1q23.3
Brief Description  dual specificity phosphatase 12
description  The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008]
  • synonyms:
  • AF119226,
  • NM_007240,
  • YVH1,
  • YVH1 protein-tyrosine phosphatase (S. cerevisiae) ortholog,
  • DUSP12,
  • uc001gbo.4,
  • serine/threonine specific protein phosphatase,
  • DUSP1,
  • HGNC:3067,
  • DUSP1,
  • OTTHUMG00000034540,
  • YVH1
  • identifiers:
  • 11266,
  • ENSG00000081721,
  • DUSP12

Genome feature

Region: gene ? Length: 7397  
Location: 1:161749768-161757164 Cyto location: 1q23.3

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

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Gene --> GO terms.



0 Pathways

32 SN Ps

5 Cross References

15 Data Sets

6 Homologues

0 Located Features

90 Rna Seq Results