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Gene : CHRNA2 Homo sapiens

Name  ? cholinergic receptor nicotinic alpha 2 subunit Cytological Location  8p21.2
Brief Description  cholinergic receptor nicotinic alpha 2 subunit
description  Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq, Nov 2009]
  • synonyms:
  • OTTHUMG00000102083,
  • uc010lur.5,
  • acetylcholine receptor, nicotinic, alpha 2 (neuronal),
  • cholinergic receptor, nicotinic, alpha 2 (neuronal),
  • HGNC:1956,
  • cholinergic receptor, nicotinic alpha 2,
  • cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal),
  • CHRNA2,
  • U62431,
  • NM_000742
  • identifiers:
  • 1135,
  • ENSG00000120903,
  • CHRNA2

Genome feature

Region: gene ? Length: 19536  
Location: 8:27459761-27479296 reverse strand Cyto location: 8p21.2


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Disease

1 Diseases

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Other

458 SN Ps

4 Cross References

17 Data Sets

67 Homologues

0 Located Features

90 Rna Seq Results