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Gene : AANAT Homo sapiens

Name  ? aralkylamine N-acetyltransferase Cytological Location  17q25.1
Brief Description  aralkylamine N-acetyltransferase
description  The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
  • synonyms:
  • arylalkylamine N-acetyltransferase,
  • uc002jro.4,
  • NM_001088,
  • OTTHUMG00000180179,
  • serotonin N-acetyltransferase,
  • U40347,
  • HGNC:19,
  • SNAT,
  • AANAT,
  • DSPS,
  • SNAT
  • identifiers:
  • 15,
  • ENSG00000129673,
  • AANAT

Genome feature

Region: gene ? Length: 17447  
Location: 17:76453351-76470797 Cyto location: 17q25.1


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Genomics

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Proteins

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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Expression

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Other

622 SN Ps

5 Cross References

17 Data Sets

5 Homologues

0 Located Features

90 Rna Seq Results