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Gene : ADRA2A Homo sapiens

Name  ? adrenoceptor alpha 2A Cytological Location  10q25.2
Brief Description  adrenoceptor alpha 2A
description  Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
  • synonyms:
  • NM_000681,
  • ADRA2R,
  • AF284095,
  • alpha-2AAR subtype C10,
  • OTTHUMG00000019050,
  • adrenergic, alpha-2A-, receptor,
  • ALPHA2AAR,
  • ADRA2R,
  • alpha-2A-adrenergic receptor,
  • ADRA2A,
  • ZNF32,
  • ADRA2,
  • ADRAR,
  • ADRAR,
  • uc001kzo.4,
  • HGNC:281,
  • ADRA2
  • identifiers:
  • 150,
  • ENSG00000150594,
  • ADRA2A

Genome feature

Region: gene ? Length: 3876  
Location: 10:111077032-111080907 Cyto location: 10q25.2


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Function

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

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Other

284 SN Ps

5 Cross References

16 Data Sets

25 Homologues

0 Located Features

90 Rna Seq Results