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Gene : DAXX Homo sapiens

Name  ? death domain associated protein Cytological Location  6p21.32
Brief Description  death domain associated protein
description  This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
  • synonyms:
  • death-associated protein 6,
  • AF006041,
  • OTTHUMG00000031203,
  • SMIM40,
  • DAP6,
  • BING2,
  • EAP1,
  • uc011drd.3,
  • DAP6,
  • HGNC:2681,
  • NM_001141969,
  • DAXX
  • identifiers:
  • 1616,
  • ENSG00000204209,
  • DAXX

Genome feature

Region: gene ? Length: 4459  
Location: 6:33318558-33323016 reverse strand Cyto location: 6p21.32


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961 SN Ps

5 Cross References

16 Data Sets

4 Homologues

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90 Rna Seq Results