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Gene : AKR1C2 Homo sapiens

Name  ? aldo-keto reductase family 1 member C2 Cytological Location  10p15.1
Brief Description  aldo-keto reductase family 1 member C2
description  This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
  • synonyms:
  • aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III),
  • BABP,
  • DD2,
  • uc057rik.1,
  • L32592,
  • DDH2,
  • DDH2,
  • HAKRD,
  • DD2,
  • SRXY8,
  • HGNC:385,
  • NM_001354,
  • MCDR2,
  • AKR1C-pseudo,
  • DD/BABP,
  • DD,
  • AKR1C2,
  • HBAB,
  • HAKRD,
  • dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III,
  • TDD,
  • OTTHUMG00000017584,
  • DD-2,
  • MCDR2,
  • BABP,
  • DD,
  • TDD,
  • testicular 17,20-desmolase deficiency
  • identifiers:
  • 1646,
  • ENSG00000151632,
  • AKR1C2

Genome feature

Region: gene ? Length: 30259  
Location: 10:4987775-5018033 reverse strand Cyto location: 10p15.1


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1 Diseases

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2011 SN Ps

5 Cross References

18 Data Sets

35 Homologues

0 Located Features

90 Rna Seq Results