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Gene : TLE5 Homo sapiens

Name  ? TLE family member 5, transcriptional modulator Cytological Location  19p13.3
Brief Description  amino-terminal enhancer of split
description  The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • NM_198969,
  • Grg-5,
  • GRG5,
  • AES-1,
  • GRG5,
  • amino-terminal enhancer of split,
  • uc002lwy.2,
  • AES,
  • AES,
  • OTTHUMG00000180567,
  • AES-2,
  • AK094591,
  • ESP1,
  • HGNC:307,
  • GRG,
  • AES
  • identifiers:
  • 166,
  • ENSG00000104964,
  • TLE5

Genome feature

Region: gene ? Length: 10198  
Location: 19:3052910-3063107 reverse strand Cyto location: 19p13.3

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Orthologues


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



0 Pathways

248 SN Ps

5 Cross References

14 Data Sets

15 Homologues

0 Located Features

90 Rna Seq Results