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Gene : DCLK2 Homo sapiens

Name  ? doublecortin like kinase 2 Cytological Location  4q31.23-q31.3
Brief Description  doublecortin like kinase 2
description  This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]
  • synonyms:
  • DCDC3,
  • HGNC:19002,
  • BC032726,
  • MGC45428,
  • DCLK2,
  • uc003ilm.5,
  • DCDC3B,
  • OTTHUMG00000161444,
  • DCAMKL2,
  • doublecortin and CaM kinase-like 2,
  • DCDC3B,
  • NM_001040260,
  • CLIK2,
  • CLICK-II,
  • doublecortin-like kinase 2,
  • DCDC3,
  • DCAMKL2,
  • CL2,
  • DCK2,
  • CLICK2,
  • DCK2
  • identifiers:
  • 166614,
  • ENSG00000170390,
  • DCLK2

Genome feature

Region: gene ? Length: 179184  
Location: 4:150078274-150257457 Cyto location: 4q31.23-q31.3


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0 Pathways

2011 SN Ps

5 Cross References

16 Data Sets

22 Homologues

0 Located Features

90 Rna Seq Results