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Gene : AGT Homo sapiens

Name  ? angiotensinogen Cytological Location  1q42.2
Brief Description  angiotensinogen
description  The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]
  • synonyms:
  • SERPINA8,
  • alpha-1 antiproteinase, antitrypsin,
  • OTTHUMG00000037757,
  • SERPINA8,
  • HGNC:333,
  • ANHU,
  • NM_000029,
  • serpin peptidase inhibitor, clade A, member 8,
  • hFLT1,
  • uc001hty.6,
  • AGT,
  • K02215
  • identifiers:
  • 183,
  • ENSG00000135744,
  • AGT

Genome feature

Region: gene ? Length: 12068  
Location: 1:230702523-230714590 reverse strand Cyto location: 1q42.2


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Gene -> HPO annotation (Human Phenotype Ontology)

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Proteins

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SNPs

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Disease

2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Expression

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Other

2011 SN Ps

5 Cross References

19 Data Sets

74 Homologues

0 Located Features

90 Rna Seq Results