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Gene : DUT Homo sapiens

Name  ? deoxyuridine triphosphatase Cytological Location  15q21.1
Brief Description  deoxyuridine triphosphatase
description  This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]
  • synonyms:
  • NM_001025248,
  • dUTP diphosphatase,
  • dUTPase,
  • M89913,
  • dUTPase,
  • OTTHUMG00000172155,
  • DUT,
  • HGNC:3078,
  • uc001zww.4,
  • dUTP pyrophosphatase
  • identifiers:
  • 1854,
  • ENSG00000128951,
  • DUT

Genome feature

Region: gene ? Length: 13383  
Location: 15:48329991-48343373 Cyto location: 15q21.1


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308 SN Ps

5 Cross References

17 Data Sets

6 Homologues

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90 Rna Seq Results