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Gene : AKT1 Homo sapiens

Name  ? AKT serine/threonine kinase 1 Cytological Location  14q32.33
Brief Description  AKT serine/threonine kinase 1
description  The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
  • synonyms:
  • PKB-ALPHA,
  • PKB,
  • CWS6,
  • PRKBA,
  • AKT1,
  • uc001ypm.4,
  • RAC,
  • NM_005163,
  • PRKBA,
  • AKT,
  • RAC-ALPHA,
  • OTTHUMG00000170795,
  • HGNC:391,
  • v-akt murine thymoma viral oncogene homolog 1,
  • PKB,
  • AKT,
  • RAC,
  • protein kinase B,
  • M63167
  • identifiers:
  • 207,
  • ENSG00000142208,
  • AKT1

Genome feature

Region: gene ? Length: 26395  
Location: 14:104769349-104795743 reverse strand Cyto location: 14q32.33


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Function

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133 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Proteins

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SNPs

Gene Report --> GWAS hit

Disease

6 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Expression

Gene(s) --> Significant SNPs (GTex data)

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Other

133 Pathways

505 SN Ps

5 Cross References

20 Data Sets

37 Homologues

0 Located Features

90 Rna Seq Results