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Gene : ETV1 Homo sapiens

Name  ? ETS variant 1 Cytological Location  7p21.2
Brief Description  ETS variant 1
description  This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2016]
  • synonyms:
  • uc021zzs.2,
  • OTTHUMG00000152403,
  • NM_004956,
  • HGNC:3490,
  • ets variant gene 1,
  • ER81,
  • ETV1,
  • ER81
  • identifiers:
  • 2115,
  • ENSG00000006468,
  • ETV1

Genome feature

Region: gene ? Length: 100197  
Location: 7:13891229-13991425 reverse strand Cyto location: 7p21.2


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0 Pathways

92 SN Ps

5 Cross References

15 Data Sets

33 Homologues

0 Located Features

90 Rna Seq Results