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Gene : FCGR3A Homo sapiens

Name  ? Fc fragment of IgG receptor IIIa Cytological Location  1q23.3
Brief Description  Fc fragment of IgG receptor IIIa
description  This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • FCGR3A,
  • FCGR3,
  • OTTHUMG00000034466,
  • BC036723,
  • HGNC:3619,
  • NM_000569,
  • FCR-10,
  • FCGRIII,
  • FCG3,
  • FCGR3,
  • IMD20,
  • CD16A,
  • IGFR3,
  • Fc fragment of IgG, low affinity IIIa, receptor (CD16a),
  • FCG3,
  • uc009wui.4,
  • CD16a,
  • CD16,
  • FCRIII,
  • Fc fragment of IgG, low affinity IIIa, receptor for (CD16),
  • FCRIIIA,
  • Fc gamma receptor IIIa,
  • CD16
  • identifiers:
  • 2214,
  • ENSG00000203747,
  • FCGR3A

Genome feature

Region: gene ? Length: 8979  
Location: 1:161541759-161550737 reverse strand Cyto location: 1q23.3


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1 Diseases

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229 SN Ps

5 Cross References

18 Data Sets

30 Homologues

0 Located Features

90 Rna Seq Results