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Gene : HAAO Homo sapiens

Name  ? 3-hydroxyanthranilate 3,4-dioxygenase Cytological Location  2p21
Brief Description  3-hydroxyanthranilate 3,4-dioxygenase
description  3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]
  • synonyms:
  • h3HAO,
  • 3-HAO,
  • HGNC:4796,
  • VCRL1,
  • HAO,
  • Z29481,
  • uc002rst.5,
  • NM_012205,
  • HAAO,
  • OTTHUMG00000152348
  • identifiers:
  • 23498,
  • ENSG00000162882,
  • HAAO

Genome feature

Region: gene ? Length: 33916  
Location: 2:42767087-42801002 reverse strand Cyto location: 2p21


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Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Expression

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2011 SN Ps

5 Cross References

20 Data Sets

5 Homologues

0 Located Features

90 Rna Seq Results