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Gene : ALOX5 Homo sapiens

Name  ? arachidonate 5-lipoxygenase Cytological Location  10q11.21
Brief Description  arachidonate 5-lipoxygenase
description  This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
  • synonyms:
  • ALOX5,
  • 5-LOX,
  • uc001jce.5,
  • 5-LOX,
  • J03571,
  • 5-LO,
  • OTTHUMG00000018081,
  • 5LPG,
  • HGNC:435,
  • LOG5,
  • NM_000698
  • identifiers:
  • 240,
  • ENSG00000012779,
  • ALOX5

Genome feature

Region: gene ? Length: 71956  
Location: 10:45374166-45446121 Cyto location: 10q11.21


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Proteins

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SNPs

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Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

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Expression

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2011 SN Ps

5 Cross References

18 Data Sets

11 Homologues

0 Located Features

90 Rna Seq Results