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Gene : ALOX5AP Homo sapiens

Name  ? arachidonate 5-lipoxygenase activating protein Cytological Location  13q12.3
Brief Description  arachidonate 5-lipoxygenase activating protein
description  This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
  • synonyms:
  • NM_001629,
  • FLAP,
  • arachidonate 5-lipoxygenase-activating protein,
  • uc001utf.3,
  • MK-886-binding protein,
  • HGNC:436,
  • ALOX5AP,
  • OTTHUMG00000016677,
  • FLAP,
  • AH001462,
  • five-lipoxygenase activating protein
  • identifiers:
  • 241,
  • ENSG00000132965,
  • ALOX5AP

Genome feature

Region: gene ? Length: 50951  
Location: 13:30713478-30764428 Cyto location: 13q12.3


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Function

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Gene -> HPO annotation (Human Phenotype Ontology)

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Genomics

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Proteins

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SNPs

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Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Expression

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Other

108 SN Ps

5 Cross References

18 Data Sets

6 Homologues

0 Located Features

90 Rna Seq Results