help  | about  | cite  | software

Gene : SPDEF Homo sapiens

Name  ? SAM pointed domain containing ETS transcription factor Cytological Location  6p21.31
Brief Description  SAM pointed domain containing ETS transcription factor
description  The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
  • synonyms:
  • bA375E1.3,
  • AF071538,
  • OTTHUMG00000014548,
  • HGNC:17257,
  • SAM pointed domain containing ets transcription factor,
  • PDEF,
  • uc003ojq.3,
  • NM_012391,
  • PDEF,
  • SPDEF,
  • bA375E1.3
  • identifiers:
  • 25803,
  • ENSG00000124664,

Genome feature

Region: gene ? Length: 18534  
Location: 6:34537800-34556333 reverse strand Cyto location: 6p21.31

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer


Gene Ontology Displayer

0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer

Gene --> Orthologues


Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



0 Pathways

17 SN Ps

5 Cross References

15 Data Sets

32 Homologues

0 Located Features

90 Rna Seq Results