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Gene : IBTK Homo sapiens

Name  ? inhibitor of Bruton tyrosine kinase Cytological Location  6q14.1
Brief Description  inhibitor of Bruton tyrosine kinase
description  Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
  • synonyms:
  • AF235049,
  • uc003pjl.2,
  • IBTK,
  • Bruton agammaglobulinemia tyrosine kinase inhibitor,
  • BTBD26,
  • inhibitor of Bruton agammaglobulinemia tyrosine kinase,
  • NM_015525,
  • DKFZP564B116,
  • HGNC:17853,
  • OTTHUMG00000015102,
  • BTKI,
  • BTBD26,
  • BTKI
  • identifiers:
  • 25998,
  • ENSG00000005700,
  • IBTK

Genome feature

Region: gene ? Length: 77768  
Location: 6:82169987-82247754 reverse strand Cyto location: 6q14.1

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0 Pathways

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Gene -> HPO annotation (Human Phenotype Ontology)

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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0 Pathways

252 SN Ps

5 Cross References

16 Data Sets

4 Homologues

0 Located Features

90 Rna Seq Results