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Gene : APEX2 Homo sapiens

Name  ? apurinic/apyrimidinic endodeoxyribonuclease 2 Cytological Location  Xp11.21
Brief Description  apurinic/apyrimidinic endodeoxyribonuclease 2
description  Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
  • synonyms:
  • OTTHUMG00000021642,
  • HGNC:17889,
  • uc004dtz.5,
  • ZGRF2,
  • APE2,
  • XTH2,
  • XTH2,
  • APE2,
  • APEXL2,
  • NM_001271748,
  • APEXL2,
  • APEX2,
  • ZGRF2,
  • AB021260,
  • zinc finger, GRF-type containing 2,
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2
  • identifiers:
  • 27301,
  • ENSG00000169188,
  • APEX2

Genome feature

Region: gene ? Length: 7551  
Location: X:55000323-55007873 Cyto location: Xp11.21


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Function

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1 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Gene --> Orthologues

Interactions

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Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

1 Pathways

46 SN Ps

5 Cross References

15 Data Sets

5 Homologues

0 Located Features

90 Rna Seq Results