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Gene : GNAS Homo sapiens

Name  ? GNAS complex locus Cytological Location  20q13.32
Brief Description  GNAS complex locus
description  This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]
  • synonyms:
  • GPSA,
  • GSP,
  • guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1,
  • GPSA,
  • SgVI,
  • NESP,
  • PITA3,
  • NM_000516,
  • secretogranin VI,
  • HGNC:4392,
  • GNAS,
  • uc061ybx.1,
  • GNAS1,
  • NESP55,
  • AHO,
  • GNAS1,
  • SCG6,
  • G protein subunit alpha S,
  • SgVI,
  • GSA,
  • SCG6,
  • NESP,
  • M21142,
  • C20orf45,
  • GNASXL,
  • OTTHUMG00000033069,
  • POH
  • identifiers:
  • 2778,
  • ENSG00000087460,
  • GNAS

Genome feature

Region: gene ? Length: 71516  
Location: 20:58839681-58911196 Cyto location: 20q13.32


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8 Diseases

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53 SN Ps

5 Cross References

20 Data Sets

23 Homologues

0 Located Features

90 Rna Seq Results