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Gene : ANGPT1 Homo sapiens

Name  ? angiopoietin 1 Cytological Location  8q23.1
Brief Description  angiopoietin 1
description  This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
  • synonyms:
  • ANGPT1,
  • NM_001146,
  • Ang1,
  • D13628,
  • KIAA0003,
  • uc003ymn.4,
  • ANG1,
  • AGPT,
  • NM_139290,
  • OTTHUMG00000164812,
  • HGNC:484,
  • AGP1
  • identifiers:
  • 284,
  • ENSG00000154188,
  • ANGPT1

Genome feature

Region: gene ? Length: 248574  
Location: 8:107249482-107498055 reverse strand Cyto location: 8q23.1


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Proteins

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SNPs

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Disease

0 Diseases

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

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Other

93 SN Ps

5 Cross References

18 Data Sets

27 Homologues

0 Located Features

90 Rna Seq Results