help  | about  | cite  | software

Gene : ANPEP Homo sapiens

Name  ? alanyl aminopeptidase, membrane Cytological Location  15q26.1
Brief Description  alanyl aminopeptidase, membrane
description  Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]
  • synonyms:
  • CD13,
  • p150,
  • alanyl (membrane) aminopeptidase,
  • ANPEP,
  • P150,
  • NM_001150,
  • GP150,
  • membrane alanyl aminopeptidase,
  • gp150,
  • CD13,
  • HGNC:500,
  • aminopeptidase N,
  • APN,
  • PEPN,
  • PEPN,
  • LAP1,
  • microsomal aminopeptidase,
  • M22324,
  • OTTHUMG00000149814,
  • aminopeptidase M,
  • uc002bop.5,
  • LAP1
  • identifiers:
  • 290,
  • ENSG00000166825,
  • ANPEP

Genome feature

Region: gene ? Length: 29958  
Location: 15:89784895-89814852 reverse strand Cyto location: 15q26.1


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Gene --> Orthologues

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

682 SN Ps

5 Cross References

17 Data Sets

28 Homologues

0 Located Features

90 Rna Seq Results