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Gene : GRM6 Homo sapiens

Name  ? glutamate metabotropic receptor 6 Cytological Location  5q35.3
Brief Description  glutamate metabotropic receptor 6
description  L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Mutations in this gene result in congenital stationary night blindness type 1B. [provided by RefSeq, May 2018]
  • synonyms:
  • GPRC1F,
  • uc003mjr.4,
  • MGLUR6,
  • MGLUR6,
  • glutamate receptor, metabotropic 6,
  • CSNB1B,
  • mGlu6,
  • U82083,
  • GRM6,
  • mGlu6,
  • HGNC:4598,
  • NM_000843,
  • GPRC1F,
  • CSNB1B,
  • OTTHUMG00000130889
  • identifiers:
  • 2916,
  • ENSG00000113262,
  • GRM6

Genome feature

Region: gene ? Length: 16797  
Location: 5:178978327-178995123 reverse strand Cyto location: 5q35.3


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Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

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Other

19 SN Ps

5 Cross References

17 Data Sets

12 Homologues

0 Located Features

90 Rna Seq Results