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Gene : ANXA7 Homo sapiens

Name  ? annexin A7 Cytological Location  10q22.2
Brief Description  annexin A7
description  Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion. [provided by RefSeq, Jul 2008]
  • synonyms:
  • J04543,
  • ANXA7,
  • HGNC:545,
  • SYNEXIN,
  • SNX,
  • uc001jua.3,
  • OTTHUMG00000018463,
  • ANX7,
  • ANX7,
  • NM_001156
  • identifiers:
  • 310,
  • ENSG00000138279,
  • ANXA7

Genome feature

Region: gene ? Length: 38985  
Location: 10:73375101-73414085 reverse strand Cyto location: 10q22.2


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0 Pathways

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5 Cross References

15 Data Sets

16 Homologues

0 Located Features

90 Rna Seq Results