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Gene : HLA-DOB Homo sapiens

Name  ? major histocompatibility complex, class II, DO beta Cytological Location  6p21.32
Brief Description  major histocompatibility complex, class II, DO beta
description  HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
  • synonyms:
  • uc011jsv.2,
  • NM_002120,
  • HGNC:4937,
  • HLA-DOB,
  • DOB,
  • HLA_DOB,
  • OTTHUMG00000031213
  • identifiers:
  • 3112,
  • ENSG00000241106,

Genome feature

Region: gene ? Length: 4286  
Location: 6:32812763-32817048 reverse strand Cyto location: 6p21.32

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0 Diseases

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39845 SN Ps

5 Cross References

15 Data Sets

27 Homologues

0 Located Features

90 Rna Seq Results