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Gene : APBB1 Homo sapiens

Name  ? amyloid beta precursor protein binding family B member 1 Cytological Location  11p15.4
Brief Description  amyloid beta precursor protein binding family B member 1
description  The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]
  • synonyms:
  • L77864,
  • RIR,
  • FE65,
  • OTTHUMG00000165454,
  • Fe65,
  • amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65),
  • RIR,
  • HGNC:581,
  • MGC:9072,
  • uc001mdc.3,
  • NM_001164,
  • APBB1
  • identifiers:
  • 322,
  • ENSG00000166313,
  • APBB1

Genome feature

Region: gene ? Length: 24707  
Location: 11:6395124-6419830 reverse strand Cyto location: 11p15.4


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SNPs

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Disease

0 Diseases

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Homology

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Expression

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Other

227 SN Ps

5 Cross References

16 Data Sets

6 Homologues

0 Located Features

90 Rna Seq Results