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Gene : APEH Homo sapiens

Name  ? acylaminoacyl-peptide hydrolase Cytological Location  3p21.31
Brief Description  acylaminoacyl-peptide hydrolase
description  This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma. [provided by RefSeq, Jul 2008]
  • synonyms:
  • D3S48E,
  • uc003cxf.4,
  • DNF15S2,
  • acylaminoacyl-peptidase,
  • APH,
  • OPH,
  • APEH,
  • N-acylaminoacyl-peptide hydrolase,
  • D3S48E,
  • HGNC:586,
  • ACPH,
  • D3F15S2,
  • OTTHUMG00000156882,
  • D38441,
  • NM_001640,
  • DNF15S2,
  • acylamino-acid-releasing enzyme,
  • AARE,
  • D3F15S2
  • identifiers:
  • 327,
  • ENSG00000164062,
  • APEH

Genome feature

Region: gene ? Length: 10407  
Location: 3:49673102-49683508 Cyto location: 3p21.31


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Disease

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2011 SN Ps

5 Cross References

16 Data Sets

7 Homologues

0 Located Features

90 Rna Seq Results