help  | about  | cite  | software

Gene : HTR2C Homo sapiens

Name  ? 5-hydroxytryptamine receptor 2C Cytological Location  Xq23
Brief Description  5-hydroxytryptamine receptor 2C
description  This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015]
  • synonyms:
  • HTR1C,
  • 5-HT2C,
  • OTTHUMG00000022226,
  • HGNC:5295,
  • 5HTR2C,
  • 5-HT1C,
  • HTR2C,
  • HTR1C,
  • NM_000868,
  • 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled,
  • uc004epu.1,
  • 5-HT2C,
  • 5-HTR2C,
  • 5-hydroxytryptamine (serotonin) receptor 2C,
  • 5HTR2C
  • identifiers:
  • 3358,
  • ENSG00000147246,
  • HTR2C

Genome feature

Region: gene ? Length: 325984  
Location: X:114584078-114910061 Cyto location: Xq23


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Gene --> Orthologues

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

314 SN Ps

5 Cross References

16 Data Sets

39 Homologues

0 Located Features

90 Rna Seq Results