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Gene : APOE Homo sapiens

Name  ? apolipoprotein E Cytological Location  19q13.32
Brief Description  apolipoprotein E
description  The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]
  • synonyms:
  • LDLCQ5,
  • OTTHUMG00000128901,
  • NM_000041,
  • K00396,
  • APOE,
  • AD2,
  • Alzheimer disease 2 (APOE*E4-associated, late onset),
  • APO-E,
  • ApoE4,
  • AD2,
  • uc002pab.4,
  • LPG,
  • HGNC:613
  • identifiers:
  • 348,
  • ENSG00000130203,
  • APOE

Genome feature

Region: gene ? Length: 3647  
Location: 19:44905749-44909395 Cyto location: 19q13.32


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Function

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

6 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Gene --> Orthologues

Interactions

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Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

261 SN Ps

5 Cross References

20 Data Sets

7 Homologues

0 Located Features

90 Rna Seq Results