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Gene : LTA Homo sapiens

Name  ? lymphotoxin alpha Cytological Location  6p21.33
Brief Description  lymphotoxin alpha
description  The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
  • synonyms:
  • uc011ioe.3,
  • LTA,
  • TNFB,
  • HGNC:6709,
  • TNFSF1,
  • TNF superfamily member 1,
  • LT,
  • lymphotoxin alpha (TNF superfamily, member 1),
  • TNLG1E,
  • NM_000595,
  • TNFB,
  • OTTHUMG00000031135,
  • LT,
  • X01393,
  • TNFSF1
  • identifiers:
  • 4049,
  • ENSG00000226979,
  • LTA

Genome feature

Region: gene ? Length: 13775  
Location: 6:31560550-31574324 Cyto location: 6p21.33


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Disease

3 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Expression

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Other

150 SN Ps

5 Cross References

17 Data Sets

12 Homologues

0 Located Features

90 Rna Seq Results