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Gene : MCM6 Homo sapiens

Name  ? minichromosome maintenance complex component 6 Cytological Location  2q21.3
Brief Description  minichromosome maintenance complex component 6
description  The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012]
  • synonyms:
  • MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae),
  • P105MCM,
  • OTTHUMG00000131739,
  • uc002tuw.5,
  • HGNC:6949,
  • minichromosome maintenance deficient (mis5, S. pombe) 6,
  • NM_005915,
  • minichromosome maintenance deficient 6 homolog (S. cerevisiae),
  • MIS5 homolog (S.pombe),
  • MCM6,
  • Mis5,
  • Mis5,
  • MCG40308
  • identifiers:
  • 4175,
  • ENSG00000076003,
  • MCM6

Genome feature

Region: gene ? Length: 36852  
Location: 2:135839626-135876477 reverse strand Cyto location: 2q21.3


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Disease

1 Diseases

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2011 SN Ps

5 Cross References

20 Data Sets

15 Homologues

0 Located Features

90 Rna Seq Results