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Gene : ADAM11 Homo sapiens

Name  ? ADAM metallopeptidase domain 11 Cytological Location  17q21.31
Brief Description  ADAM metallopeptidase domain 11
description  This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
  • synonyms:
  • a disintegrin and metalloproteinase domain 11,
  • ADAM11,
  • MDC,
  • HGNC:189,
  • metalloproteinase-like, disintegrin-like, cysteine-rich protein,
  • uc002ihh.4,
  • MDC,
  • D17390,
  • NM_002390,
  • OTTHUMG00000179038
  • identifiers:
  • 4185,
  • ENSG00000073670,
  • ADAM11

Genome feature

Region: gene ? Length: 22696  
Location: 17:44759151-44781846 Cyto location: 17q21.31


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Function

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

2011 SN Ps

5 Cross References

15 Data Sets

28 Homologues

0 Located Features

90 Rna Seq Results