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Gene : MDM4 Homo sapiens

Name  ? MDM4 regulator of p53 Cytological Location  1q32.1
Brief Description  MDM4, p53 regulator
description  This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
  • synonyms:
  • Mdm4 p53 binding protein homolog (mouse),
  • MDMX,
  • HGNC:6974,
  • NM_002393,
  • AF007111,
  • MDMX,
  • mouse double minute 4, human homolog of; p53-binding protein,
  • MRP1,
  • HDMX,
  • MDM4,
  • MDM4, p53 regulator,
  • OTTHUMG00000035877,
  • uc001hba.4,
  • Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse),
  • HDMX
  • identifiers:
  • 4194,
  • ENSG00000198625,
  • MDM4

Genome feature

Region: gene ? Length: 41744  
Location: 1:204516377-204558120 Cyto location: 1q32.1

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0 Diseases

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414 SN Ps

5 Cross References

18 Data Sets

9 Homologues

0 Located Features

90 Rna Seq Results