help  | about  | cite  | software

Gene : ASIP Homo sapiens

Name  ? agouti signaling protein Cytological Location  20q11.22
Brief Description  agouti signaling protein
description  In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]
  • synonyms:
  • AGSW,
  • AGTI,
  • uc061wig.1,
  • agouti (mouse)-signaling protein,
  • ASP,
  • ASIP,
  • agouti signaling protein, nonagouti homolog (mouse),
  • HGNC:745,
  • ASP,
  • NM_001672,
  • nonagouti homolog (mouse),
  • SHEP9,
  • OTTHUMG00000032289,
  • AGTIL,
  • AGTIL
  • identifiers:
  • 434,
  • ENSG00000101440,
  • ASIP

Genome feature

Region: gene ? Length: 82852  
Location: 20:34186493-34269344 Cyto location: 20q11.22


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

1 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Gene --> Orthologues

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

1 Pathways

381 SN Ps

4 Cross References

16 Data Sets

4 Homologues

0 Located Features

90 Rna Seq Results