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Gene : MXI1 Homo sapiens

Name  ? MAX interactor 1, dimerization protein Cytological Location  10q25.2
Brief Description  MAX interactor 1, dimerization protein
description  Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]
  • synonyms:
  • MXD2,
  • MAX interactor 1,
  • MXI,
  • MAD2,
  • bHLHc11,
  • HGNC:7534,
  • OTTHUMG00000019033,
  • NM_130439,
  • uc001kyy.3,
  • MXD2,
  • bHLHc11,
  • MXI1,
  • MXI,
  • MAX interacting protein 1,
  • MAD2,
  • BC016678
  • identifiers:
  • 4601,
  • ENSG00000119950,
  • MXI1

Genome feature

Region: gene ? Length: 79761  
Location: 10:110207605-110287365 Cyto location: 10q25.2


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Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Mouse Gene --> Allele [Phenotype]

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0 Pathways

563 SN Ps

5 Cross References

18 Data Sets

8 Homologues

0 Located Features

90 Rna Seq Results