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Gene : ZFHX3 Homo sapiens

Name  ? zinc finger homeobox 3 Cytological Location  16q22.2-q22.3
Brief Description  zinc finger homeobox 3
description  This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
  • synonyms:
  • HGNC:777,
  • ZNF927,
  • uc002fck.4,
  • ZFHX3,
  • AT-binding transcription factor 1,
  • ATBF1,
  • ATBT,
  • D10250,
  • ATBF1,
  • OTTHUMG00000137599,
  • NM_006885,
  • ZNF927
  • identifiers:
  • 463,
  • ENSG00000140836,
  • ZFHX3

Genome feature

Region: gene ? Length: 275751  
Location: 16:72782885-73058635 reverse strand Cyto location: 16q22.2-q22.3


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Disease

1 Diseases

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115 SN Ps

5 Cross References

18 Data Sets

8 Homologues

1 Located Features

90 Rna Seq Results