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Gene : ATF4 Homo sapiens

Name  ? activating transcription factor 4 Cytological Location  22q13.1
Brief Description  activating transcription factor 4
description  This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]
  • synonyms:
  • CREB-2,
  • TXREB,
  • TXREB,
  • CREB2,
  • tax-responsive enhancer element B67,
  • ATF4,
  • NM_001675,
  • TAXREB67,
  • HGNC:786,
  • TAXREB67,
  • D90209,
  • CREB-2,
  • OTTHUMG00000151099,
  • activating transcription factor 4 (tax-responsive enhancer element B67),
  • uc021wpz.2
  • identifiers:
  • 468,
  • ENSG00000128272,
  • ATF4

Genome feature

Region: gene ? Length: 8193  
Location: 22:39514494-39522686 Cyto location: 22q13.1


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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

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2011 SN Ps

5 Cross References

15 Data Sets

13 Homologues

0 Located Features

90 Rna Seq Results