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Gene : OAS1 Homo sapiens

Name  ? 2'-5'-oligoadenylate synthetase 1 Cytological Location  12q24.13
Brief Description  2'-5'-oligoadenylate synthetase 1
description  This gene is induced by interferons and encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, Feb 2016]
  • synonyms:
  • OIASI,
  • HGNC:8086,
  • OIAS,
  • OTTHUMG00000169792,
  • 2',5'-oligoadenylate synthetase 1 (40-46 kD),
  • E18/E16,
  • IFI-4,
  • OIASI,
  • OAS1,
  • OIAS,
  • uc001tuc.4,
  • 2'-5'-oligoadenylate synthetase 1, 40/46kDa,
  • IFI-4,
  • X04371,
  • NM_001032409
  • identifiers:
  • 4938,
  • ENSG00000089127,
  • OAS1

Genome feature

Region: gene ? Length: 25414  
Location: 12:112906777-112932190 Cyto location: 12q24.13


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Gene -> HPO annotation (Human Phenotype Ontology)

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Genomics

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Proteins

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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Expression

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Other

861 SN Ps

5 Cross References

17 Data Sets

17 Homologues

0 Located Features

90 Rna Seq Results