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Gene : OAS2 Homo sapiens

Name  ? 2'-5'-oligoadenylate synthetase 2 Cytological Location  12q24.13
Brief Description  2'-5'-oligoadenylate synthetase 2
description  This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
  • synonyms:
  • OTTHUMG00000169802,
  • NM_001032731,
  • uc001tuj.4,
  • 2'-5'-oligoadenylate synthetase 2 (69-71 kD),
  • M87284,
  • 2'-5'-oligoadenylate synthetase 2, 69/71kDa,
  • OAS2,
  • HGNC:8087
  • identifiers:
  • 4939,
  • ENSG00000111335,
  • OAS2

Genome feature

Region: gene ? Length: 33258  
Location: 12:112978466-113011723 Cyto location: 12q24.13


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Gene -> HPO annotation (Human Phenotype Ontology)

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Genomics

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Proteins

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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Expression

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Other

179 SN Ps

5 Cross References

16 Data Sets

5 Homologues

0 Located Features

90 Rna Seq Results