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Gene : OGG1 Homo sapiens

Name  ? 8-oxoguanine DNA glycosylase Cytological Location  3p25.3
Brief Description  8-oxoguanine DNA glycosylase
description  This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]
  • synonyms:
  • OTTHUMG00000097091,
  • MUTM,
  • OGG1 type 1g,
  • OGG1 type 1h,
  • HGNC:8125,
  • HMMH,
  • MUTM,
  • OGH1,
  • HMMH,
  • OGH1,
  • HOGG1,
  • OGG1 type 1d,
  • OGG1 type 1e,
  • HOGG1,
  • NM_016821,
  • OGG1,
  • uc003bsj.4,
  • U96710,
  • 8-hydroxyguanine DNA glycosylase
  • identifiers:
  • 4968,
  • ENSG00000114026,
  • OGG1

Genome feature

Region: gene ? Length: 38303  
Location: 3:9749944-9788246 Cyto location: 3p25.3


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Proteins

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SNPs

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Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

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Homology

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Expression

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Other

27 SN Ps

5 Cross References

19 Data Sets

5 Homologues

0 Located Features

90 Rna Seq Results