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Gene : ASCC1 Homo sapiens

Name  ? activating signal cointegrator 1 complex subunit 1 Cytological Location  10q22.1
Brief Description  activating signal cointegrator 1 complex subunit 1
description  This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
  • synonyms:
  • NM_015947,
  • uc021pso.1,
  • ASC1p50,
  • HGNC:24268,
  • SMABF2,
  • CGI-18,
  • ASC1p50,
  • p50,
  • Em:AC022392.3,
  • AY013290,
  • CGI-18,
  • OTTHUMG00000018434,
  • ASCC1
  • identifiers:
  • 51008,
  • ENSG00000138303,
  • ASCC1

Genome feature

Region: gene ? Length: 122746  
Location: 10:72096032-72218777 reverse strand Cyto location: 10q22.1


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Gene -> HPO annotation (Human Phenotype Ontology)

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Proteins

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SNPs

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Disease

2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

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Other

2011 SN Ps

5 Cross References

19 Data Sets

5 Homologues

0 Located Features

90 Rna Seq Results