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Gene : ANAPC5 Homo sapiens

Name  ? anaphase promoting complex subunit 5 Cytological Location  12q24.31
Brief Description  anaphase promoting complex subunit 5
description  This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008]
  • synonyms:
  • ANAPC5,
  • APC5,
  • AF191339,
  • uc001uag.4,
  • HGNC:15713,
  • APC5,
  • OTTHUMG00000169157,
  • NM_001137559
  • identifiers:
  • 51433,
  • ENSG00000089053,
  • ANAPC5

Genome feature

Region: gene ? Length: 45965  
Location: 12:121308245-121354209 reverse strand Cyto location: 12q24.31


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Function

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41 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> Chromosomal location.

Gene --> GO terms.

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Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

41 Pathways

239 SN Ps

5 Cross References

16 Data Sets

7 Homologues

0 Located Features

90 Rna Seq Results