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Gene : PFKFB3 Homo sapiens

Name  ? 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Cytological Location  10p15.1
Brief Description  6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
description  The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
  • synonyms:
  • iPFK-2,
  • HGNC:8874,
  • OTTHUMG00000017621,
  • NM_004566,
  • PFKFB3,
  • PFK2,
  • IPFK2,
  • uc057rmz.1
  • identifiers:
  • 5209,
  • ENSG00000170525,
  • PFKFB3

Genome feature

Region: gene ? Length: 109771  
Location: 10:6144878-6254648 Cyto location: 10p15.1


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Disease

0 Diseases

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21 SN Ps

5 Cross References

17 Data Sets

12 Homologues

0 Located Features

90 Rna Seq Results