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Gene : ADAM22 Homo sapiens

Name  ? ADAM metallopeptidase domain 22 Cytological Location  7q21.12
Brief Description  ADAM metallopeptidase domain 22
description  This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]
  • synonyms:
  • OTTHUMG00000137417,
  • AB009671,
  • MDC2,
  • EIEE61,
  • NM_021723,
  • MDC2,
  • uc003ujn.4,
  • a disintegrin and metalloproteinase domain 22,
  • ADAM22,
  • metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2,
  • HGNC:201,
  • ADAM 22
  • identifiers:
  • 53616,
  • ENSG00000008277,
  • ADAM22

Genome feature

Region: gene ? Length: 268747  
Location: 7:87934143-88202889 Cyto location: 7q21.12


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Gene -> HPO annotation (Human Phenotype Ontology)

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Genomics

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Proteins

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SNPs

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Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Expression

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2011 SN Ps

5 Cross References

18 Data Sets

28 Homologues

0 Located Features

90 Rna Seq Results