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Gene : PML Homo sapiens

Name  ? promyelocytic leukemia Cytological Location  15q24.1
Brief Description  promyelocytic leukemia
description  The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
  • synonyms:
  • PML,
  • NM_002675,
  • RNF71,
  • OTTHUMG00000137607,
  • AB208950,
  • MYL,
  • TRIM19,
  • RNF71,
  • MYL,
  • TRIM19,
  • uc002awv.4,
  • HGNC:9113,
  • PP8675
  • identifiers:
  • 5371,
  • ENSG00000140464,
  • PML

Genome feature

Region: gene ? Length: 53147  
Location: 15:73994673-74047819 Cyto location: 15q24.1


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Disease

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170 SN Ps

5 Cross References

18 Data Sets

17 Homologues

0 Located Features

90 Rna Seq Results