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Gene : XRN1 Homo sapiens

Name  ? 5'-3' exoribonuclease 1 Cytological Location  3q23
Brief Description  5'-3' exoribonuclease 1
description  This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
  • synonyms:
  • SEP1,
  • uc003eus.4,
  • XRN1,
  • OTTHUMG00000159251,
  • HGNC:30654,
  • AY137776,
  • NM_019001,
  • SEP1
  • identifiers:
  • 54464,
  • ENSG00000114127,
  • XRN1

Genome feature

Region: gene ? Length: 141456  
Location: 3:142306607-142448062 reverse strand Cyto location: 3q23


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Function

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Gene -> HPO annotation (Human Phenotype Ontology)

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Genomics

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Proteins

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SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

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Other

267 SN Ps

5 Cross References

16 Data Sets

8 Homologues

0 Located Features

90 Rna Seq Results